fbpx
Sign up now!
Don't show this again

Thank you for confirming your subscription!

(And remember, if ever you want to change your email preferences or unsubscribe, just click on the links at the bottom of any email.)

We’re glad you’re enjoying Poultry Health Today.
Access is free but you’ll need to register to view more content.
Already registered? Sign In
Tap to download the app
X
Share
X

REPORTS

Collect articles and features into your own report to read later, print or share with others

Create a New Report

Favorites

Read Later

Create a new report

Report title (required) Brief description (optional)
CREATE
X
NEXT
POULTRY PORK FISH
follow us


You must be logged in to edit your profile.

Favorites Read Later My Reports PHT Special Reports
Poultry Health Today is equipped with some amazing (and free) tools for organizing and sharing content, as well as creating your own magazines and special reports. To access them, please register today.
Sponsored by Zoetis

Sponsored By Zoetis

.
Poulvac ST Salmonella

Poulvac® ST cross-protects against different Salmonella serotypes

website builder Salmonella vaccination is a vital part of an integrated approach to reducing the Salmonella load during the broiler life cycle, said Manuel Da Costa, DVM, PhD, associate director, Outcomes Research, Zoetis.

Salmonella control is an integrated system, where everything done in the production chain will impact other steps in the process. It starts at the parent stock level, goes through live production and ends at the processing plant. Vaccination plays a key role in this integrated control process, he said.

Shifting serotypes

A major challenge for the poultry industry is that the most prevalent Salmonella serotypes change over time. Making updates to vaccines to reflect the challenge strain is difficult; therefore, utilizing existing live vaccines that cross-protect against several Salmonella strains can be a better solution. That’s where Poulvac® ST vaccination fits in, Da Costa said.

Cross-protection is key

In studies, Poulvac ST was shown to cross-protect against Salmonella strains in serogroups B, C and D. Vaccines that cross-protect can benefit poultry complexes finding various strains in their processing plant, he said.

A series of 42-day challenges evaluated the percentage of ceca positive for Salmonella in vaccinated and unvaccinated birds. Vaccination with Poulvac ST protected broilers against Salmonella serogroups B, C and D, including S. Typhimurium, S. Heidelberg, S. Enteritidis, S. Kentucky and S. Hadar, Da Costa said.1

In comparison to the unvaccinated controls in these studies, Salmonella recovered in the ceca was reduced in birds vaccinated with Poulvac ST including: S. Typhimurium (Group B) 60% reduction; S. Heidelberg (Group B) 54% reduction; S. Enteritidis (Group D) 55% reduction; S. Kentucky (Group C) 34% reduction; and S. Hadar (Group C) 25% reduction.2

In two further studies, the effectiveness of Poulvac ST against S. Infantis in the ceca and liver/spleen was measured, Da Costa noted.

In the first study, birds were challenged with S. Infantis at 31 days of age and then evaluated at 41 days of age. Compared to the unvaccinated controls, birds vaccinated with Poulvac ST showed a 1.7-log reduction in the ceca, which translates to a lower Salmonella load going into the processing plant, Da Costa said.3

When evaluating Salmonella prevalence in the liver and spleen, vaccination with Poulvac ST resulted in a 9% reduction in S. Infantis, compared to controls, when broilers were directly challenged. There was also an 18% reduction in S. Infantis, compared to the controls, when broilers were horizontally exposed, he noted.4

Concurrently, the liver/spleen of vaccinated birds directly challenged had a 1.01-log reduction in S. Infantis versus the respective controls. The reduction was even greater when broilers were horizontally exposed, with the vaccinated birds having a 1.35-log reduction compared to the controls, he said.5

Early vaccination is a must

Poulvac ST, which is administered by spray at the hatchery and field boosted at 2 weeks, protects broilers throughout their life — from early challenges at the hatchery all the way to field challenges later in life, Da Costa said.

“It’s really important to apply the vaccine in the hatchery as the broilers are more susceptible to Salmonella early on,”6 he said.

The vaccine is ingested and colonizes the gut. This prevents wild-type Salmonella from infecting the bird via competitive exclusion.7 The vaccine also triggers the birds’ immune responses, which can protect them throughout growout, he explained.

“Our research results showed that the vaccine did not persist more than 3 weeks post vaccination. It should not be reisolated and recovered at the processing plant,” Da Costa said. This reduces the risk of cross-contamination at the processing plant and helps reduce false positives.

Live Salmonella vaccines control bacteria from the inside out and should be considered a key component of a producer’s Salmonella-control program, as vaccination lowers the Salmonella load going into the processing plant, he said.

Overall, Poulvac ST provides a balance between efficacy — increasing immunity and reducing Salmonella in the birds — and safety — lowering the risk of Salmonella positives at the plant — Da Costa said.

 

 


1 Data on file. Study Report Nos. B-393-98-A6.R; B-393-98-A8.R; B-393-99-A2.R; B-393-00-A1.R; B-393-01-A1.R. Zoetis, Inc.
2 Ibid.
3 Data on file. Study Report No.  032419-KL-70AQO-KC6023. Zoetis, Inc.
4 Data on file. Study Report No. 03-19-7 ADMJ. Zoetis, Inc.
5 Ibid.
7 Methner U, Berndt A, Steinback G. Combination of Competitive Exclusion and Immunization with an Attenuated Live Salmonella Vaccine Strain in Chickens. Avian Dis 2001;45-3:  631-638.

 

 

 

 

 

All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted.

 

©2021 Zoetis Services LLC.       All rights reserved.        BIO-00312

 

 

Share It
Salmonella vaccination is a vital part of an integrated approach to reducing the Salmonella load during the broiler life cycle, said Manuel Da Costa, DVM, PhD, associate director, Outcomes Research, Zoetis.

Click an icon to share this information with your industry contacts.



Posted on August 24, 2021

tags: , ,
RELATED NEWS



You must be logged in to edit your profile.

Google Translate is provided on this website as a reference tool. However, Poultry Health Today and its sponsor and affiliates do not guarantee in any way the accuracy of the translated content and are not responsible for any event resulting from the use of the translation provided by Google. By choosing a language other than English from the Google Translate menu, the user agrees to withhold all liability and/or damage that may occur to the user by depending on or using the translation by Google.